148 citations · 1k across the 43 of their papers we have counts for
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Non-equilibrium chromosome looping via molecular slip-links
C. A. Brackley, J. Johnson, D. Michieletto +4
We propose a model for the formation of chromatin loops based on the diffusive sliding of a DNA-bound factor which can dimerise to form a molecular slip-link. Our slip-links mimic…
A Single Nucleotide Resolution Model for Large-Scale Simulations of Double Stranded DNA
Y. A. G. Fosado, D. Michieletto, J. Allan +3
The computational modelling of DNA is becoming crucial in light of new advances in DNA nanotechnology, single-molecule experiments and in vivo DNA tampering. Here we present a meso…
Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains
C. A. Brackley, B. Liebchen, D. Michieletto +3
Fluorescence microscopy reveals that the contents of many (membrane-free) nuclear "bodies" exchange rapidly with the soluble pool whilst the underlying structure persists; such obs…
A Polymer Model with Epigenetic Recolouring Reveals a Pathway for the de novo Establishment and 3D Organisation of Chromatin Domains
Davide Michieletto, Enzo Orlandini, Davide Marenduzzo
One of the most important problems in development is how epigenetic domains can be first established, and then maintained, within cells. To address this question, we propose a fram…
Chromosome-wide simulations uncover folding pathway and 3D organization of interphase chromosomes
Davide Michieletto, Davide Marenduzzo, Ajazul H. Wani
Three-dimensional interphase organization of metazoan genomes has been linked to cellular identity. However, the principles governing 3D interphase genome architecture and its fait…