148 citations · 1k across the 43 of their papers we have counts for
9 papers · 1 filter
Dynamical Entanglement and Cooperative Dynamics in Entangled Solutions of Ring and Linear Polymers
Davide Michieletto, Takahiro Sakaue
Understanding how entanglements affect the behaviour of polymeric complex fluids is an open challenge in many fields. To elucidate the nature and consequence of entanglements in de…
Simplifying Topological Entanglements by Entropic Competition of Slip-Links
Andrea Bonato, Davide Marenduzzo, Davide Michieletto
Topological entanglements are abundant, and often detrimental, in polymeric systems in biology and materials science. Here we theoretically investigate the topological simplificati…
Polymer Modelling Predicts Chromosome Reorganisation in Senescence
Michael Chiang, Davide Michieletto, Chris A. Brackley +4
Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polyme…
Simulating topological domains in human chromosomes with a fitting-free model
C. A. Brackley, D. Michieletto, F. Mouvet +4
We discuss a polymer model for the 3D organization of human chromosomes. A chromosome is represented by a string of beads, with each bead being "colored" according to 1D bioinforma…
Non-Equilibrium Effects of Molecular Motors on Polymers
M. Foglino, E. Locatelli, C. A. Brackley +3
We present a generic coarse-grained model to describe molecular motors acting on polymer substrates, mimicking, for example, RNA polymerase on DNA or kinesin on microtubules. The p…
Extrusion without a motor: a new take on the loop extrusion model of genome organization
C. A. Brackley, J. Johnson, D. Michieletto +4
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangeme…
Supercoiling Enhances DNA Mobility by Reducing Threadings and Entanglements
Jan Smrek, Davide Michieletto
DNA is increasingly employed for bio and nanotechnology thanks to its exquisite versatility and designability. Most of its use is limited to linearised and torsionally relaxed DNA…
Persistence Homology Of Entangled Rings
Fabio Landuzzi, Takenobu Nakamura, Davide Michieletto +1
Topological constraints (TCs) between polymers determine the behaviour of complex fluids such as creams, oils and plastics. Most of the polymer solutions used every day life employ…
Separation of Geometrical and Topological Entanglement in Confined Polymers Driven Out-Of-Equilibrium
Davide Michieletto, Enzo Orlandini, Matthew S Turner +1
We use Brownian dynamics simulations and advanced topological profiling methods to characterize the out-of-equilibrium evolution of self-entanglement in linear polymers confined in…