108 citations · 112 across the 5 of their papers we have counts for
11 papers
Substantial regional variation in substitution rates in the human genome: importance of GC content, gene density and telomere-specific effects
Peter F Arndt, Terence Hwa, Dmitri A Petrov
This study presents the first global, 1 Mbp level analysis of patterns of nucleotide substitutions along the human lineage. The study is based on the analysis of a large amount of…
Transcriptional Regulation by the Numbers 2: Applications
Lacramioara Bintu, Nicolas E. Buchler, Hernan G. Garcia +5
With the increasing amount of experimental data on gene expression and regulation, there is a growing need for quantitative models to describe the data and relate them to the diffe…
Transcriptional Regulation by the Numbers 1: Models
Lacramioara Bintu, Nicolas E. Buchler, Hernan G. Garcia +4
The study of gene regulation and expression is often discussed in quantitative terms. In particular, the expression of genes is regularly characterized with respect to how much, ho…
The style of genetic computing
Nicolas E. Buchler, Ulrich Gerland, Terence Hwa
Cells receive a wide variety of cellular and environmental signals, which must be processed combinatorially to generate specific and timely genetic responses. We present here a the…
Distinct changes of genomic biases in nucleotide substitution at the time of mammalian radiation
Peter F. Arndt, Dmitri A. Petrov, Terence Hwa
Differences in the regional substitution patterns in the human genome created patterns of large-scale variation of base composition known as genomic isochores. To gain insight into…
On the Selection and Evolution of Regulatory DNA Motifs
Ulrich Gerland, Terence Hwa
The mutation and selection of regulatory DNA sequences is presented as an ideal model system of molecular evolution where genotype, phenotype, and fitness can be explicitly and ind…