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physics.bio-ph2001
On the Selection and Evolution of Regulatory DNA Motifs
Ulrich Gerland, Terence Hwa
The mutation and selection of regulatory DNA sequences is presented as an ideal model system of molecular evolution where genotype, phenotype, and fitness can be explicitly and ind…
physics.bio-ph2001
DNA Sequence Evolution with Neighbor-Dependent Mutation
Peter F. Arndt, Christopher B. Burge, Terence Hwa
We introduce a model of DNA sequence evolution which can account for biases in mutation rates that depend on the identity of the neighboring bases. An analytic solution for this cl…