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Deterministic characterization of stochastic genetic circuits
Matthew Scott, Terence Hwa, Brian Ingalls
For cellular biochemical reaction systems where the numbers of molecules is small, significant noise is associated with chemical reaction events. This molecular noise can give rise…
Stochastic fluctuations in metabolic pathways
Erel Levine, Terence Hwa
Fluctuations in the abundance of molecules in the living cell may affect its growth and well being. For regulatory molecules (e.g., signaling proteins or transcription factors), fl…
Quantitative Characterization of Combinatorial Transcriptional Control of the Lactose Operon of E. coli
T. E. Kuhlman, Z. Zhang, M. H. Saier +1
It is the goal of systems biology to understand the behavior of the whole in terms of the knowledge of the parts. This is hard to achieve in many cases due to the difficulty of cha…
Designing sequential transcription logic: a simple genetic circuit for conditional memory
Georg Fritz, Nicolas E. Buchler, Terence Hwa +1
The ability to learn and respond to recurrent events depends on the capacity to remember transient biological signals received in the past. Moreover, it may be desirable to remembe…