399 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- Rice UniversityUS17 papers
- The University of Texas Health Science Center at HoustonUS17 papers
- The University of Texas at AustinUS13 papers
- Harvard UniversityUS12 papers
- Baylor College of MedicineUS10 papers
- The University of Texas Southwestern Medical CenterUS9 papers
- University of PennsylvaniaUS8 papers
- Massachusetts General HospitalUS7 papers
- Stanford UniversityUS7 papers
- Technical University of MunichDE7 papers
- University of Alabama at BirminghamUS7 papers
- University of North Carolina at Chapel HillUS7 papers
39 papers · 1 filter
Ridge-filter crosstalk in conformal proton FLASH planning: dependence on beamlet pitch and iterative mitigation
Zongsheng Hu, Yuting Li, Henry Meyer +5
Objective: Patient-specific ridge filters (PSRFs) can enable conformal single-energy proton FLASH delivery without energy switching. However, converting optimized spot-based dose d…
Bi-level Multi-criteria Optimization for Risk-informed Radiotherapy
Mara Schubert, Katrin Teichert, Zhongxing Liao +2
In radiation therapy (RT) treatment planning, multi-criteria optimization (MCO) supports efficient plan selection but is usually solved for population-based dosimetric criteria and…
OAR-Weighted Dice Score: A spatially aware, radiosensitivity aware metric for target structure contour quality assessment
Lucas McCullum, Kareem A. Wahid, Barbara Marquez +1
The Dice Similarity Coefficient (DSC) is the current de facto standard to determine agreement between a reference segmentation and one generated by manual / auto-contouring approac…
Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform
Fada Guan, Dadi Jiang, Xiaochun Wang +12
Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fi…
On the acceptance, commissioning, and quality assurance of electron FLASH units
Allison Palmiero, Kevin Liu, Julie Colnot +15
Background & Purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventio…
A molecular dynamics simulation of the abrupt changes in the thermodynamic properties of water after formation of nano-bubbles / nano-cavities induced by passage of charged particles
Ramin Abolfath, Niayesh Afshordi, Sohrab Rahvar +6
We present a multi-scale formalism that accounts for the formation of nano-scale bubbles/cavities owing to a burst of water molecules after the passage of high energy charged parti…
Development of novel ionization chambers for reference dosimetry in electron FLASH radiotherapy
Kevin Liu, Shannon Holmes, Ahtesham Ullah Khan +4
The aim of this study was to optimize the design and performance of parallel plate ion chambers for use in ultra-high dose rate (UHDR) dosimetry applications, and evaluate their po…
Characterization of a novel time-resolved, real-time scintillation dosimetry system for ultra-high dose rate radiation therapy applications
Alexander Baikalov, Daline Tho, Kevin Liu +3
Background: Scintillation dosimetry has promising qualities for ultra-high dose rate (UHDR) radiotherapy (RT), but no system has shown compatibility with mean dose rates ($\bar{DR}…
The status and challenges for prostate SBRT treatments in United States proton therapy centers: An NRG Oncology practice survey
Jiajian Shen, Paige A. Taylor, Carlos E. Vargas +8
A survey was designed to inquire about the practice of proton SBRT treatment for prostate cancer. The survey was distributed to all 30 proton therapy centers in the United States t…
Dosimetric calibration of an anatomically specific ultra-high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments
Jinghui Wang, Stavros Melemenidis, Rakesh Manjappa +16
We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiolog…
Dynamic CBCT Imaging using Prior Model-Free Spatiotemporal Implicit Neural Representation (PMF-STINR)
Hua-Chieh Shao, Mengke Tielige, Tinsu Pan +1
Dynamic cone-beam computed tomography (CBCT) can capture high-spatial-resolution, time-varying images for motion monitoring, patient setup, and adaptive planning of radiotherapy. H…
Evolving Horizons in Radiotherapy Auto-Contouring: Distilling Insights, Embracing Data-Centric Frameworks, and Moving Beyond Geometric Quantification
Kareem A. Wahid, Carlos E. Cardenas, Barbara Marquez +8
Deep learning has significantly advanced the potential for automated contouring in radiotherapy planning. In this manuscript, guided by contemporary literature, we underscore three…
Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies
Peder EZ Larson, Jenna ML Bernard, James A Bankson +16
MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney dise…
Dynamic Cone-beam CT Reconstruction using Spatial and Temporal Implicit Neural Representation Learning (STINR)
You Zhang, Tielige Mengke
Objective: Dynamic cone-beam CT (CBCT) imaging is highly desired in image-guided radiation therapy to provide volumetric images with high spatial and temporal resolutions to enable…
Deep Learning-Based Dose Prediction for Automated, Individualized Quality Assurance of Head and Neck Radiation Therapy Plans
Mary P. Gronberg, Beth M. Beadle, Adam S. Garden +20
Purpose: This study aimed to use deep learning-based dose prediction to assess head and neck (HN) plan quality and identify suboptimal plans. Methods: A total of 245 VMAT HN plans…
Automation of Radiation Treatment Planning for Rectal Cancer
Kai Huang, Prajnan Das, Adenike M. Olanrewaju +9
To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-plan…
OpenKBP-Opt: An international and reproducible evaluation of 76 knowledge-based planning pipelines
Aaron Babier, Rafid Mahmood, Binghao Zhang +56
We establish an open framework for developing plan optimization models for knowledge-based planning (KBP) in radiotherapy. Our framework includes reference plans for 100 patients w…
The effect of non-ionizing excitations on the diffusion of ion species and inter-track correlations in FLASH ultra-high dose rate radiotherapy
Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch +2
We present a microscopic mechanism that accounts for the outward burst of "cold" ion species (IS) in a high-energy particle track due to coupling with ''hot" non-ion species (NIS).…
Optimization of FLASH Proton Beams Using a Track-Repeating Algorithm
Qianxia Wang, Uwe Titt, Radhe Mohan +4
Methods: A phase space file in a plane at 202 mm downstream of the beam exit window is generated through tuning parameters to match FDC results with measured or MCNPX Monte Carlo-s…
Beam data modeling of linear accelerators (linacs) through machine learning and its potential applications in fast and robust linac commissioning and quality assurance
Wei Zhao, Ishan Patil, Bin Han +3
Background and purpose: To propose a novel machine learning-based method for reliable and accurate modeling of linac beam data applicable to the processes of linac commissioning an…
Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation
Ramin Abolfath, David Grosshans, Radhe Mohan
We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury obser…
Evaluation of the Visibility and Artifacts of 11 Common Fiducial Markers for Image-Guided Stereotactic Body Radiation Therapy in the Abdomen
Jordan M. Slagowski, Lauren E. Colbert, Irina M. Cazacu +8
The purpose of this study was to quantitatively evaluate the visibility and artifacts of commercially available fiducial markers in order to optimize their selection for image-guid…
3D source tracking and error detection in HDR using two independent scintillator dosimetry systems
Haydee M. Linares Rosales, Jacob G. Johansen, Gustavo Kertzscher +3
The high dose gradients near the source characteristics of brachytherapy are equivalent to nefarious effects if unnoticed errors take place during the patient treatment. In vivo do…
A modular phantom and software to characterize 3D geometric distortion in MRI
Jordan M. Slagowski, Yao Ding, Manik Aima +8
MRI offers outstanding soft tissue contrast that may reduce uncertainties in target and organ-at-risk delineation and enable online adaptive image-guided treatment. Spatial distort…