82 citations · 135 across the 6 of their papers we have counts for
6 papers
Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform
Fada Guan, Dadi Jiang, Xiaochun Wang +12
Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fi…
Oxygen depletion in FLASH ultra-high-dose-rate radiotherapy: A molecular dynamics simulation
Ramin Abolfath, David Grosshans, Radhe Mohan
We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury obser…
A New Approach to Modeling the Microdosimetry of Proton Therapy Beams
Ramin Abolfath, Yusuf Helo, David J. Carlson +3
{\bf Introduction}: To revisit the formulation of the mean chord length in microdosimetry and replace it by the particle mean free path appropriate for modelings in radio-biology.…
A DNA damage multi-scale model for NTCP in proton and hadron therapy
Ramin Abolfath, Chris Peeler, Dragan Mirkovic +2
{\bf Purpose}: To develop a first principle and multi-scale model for normal tissue complication probability (NTCP) as a function of dose and LET for proton and in general for part…
Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control
Ramin Abolfath, Yusuf Helo, Lawrence Bronk +3
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy.…
A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data
Ramin Abolfath, Christopher R. Peeler, Mark Newpower +3
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams. Our fitt…