240 citations
- Universitätsmedizin GöttingenDE13 papers
- Medical University of ViennaAT10 papers
- Roche (Switzerland)CH10 papers
- University of GöttingenDE9 papers
- Pfizer (United States)US6 papers
- Tris Pharma (United States)US6 papers
- Lancaster UniversityGB5 papers
- MRC Biostatistics UnitGB5 papers
- Novartis (United States)US5 papers
- University Hospital MagdeburgDE5 papers
- Boehringer Ingelheim (Germany)DE4 papers
- Newcastle UniversityGB4 papers
35 papers · 1 filter
Confidence intervals for two-stage adaptive designs with subpopulation selection
Enyu Li, Nigel Stallard, Ekkehard Glimm +2
We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs all…
Inverse Probability Weighting for Recurrent Event Models
Jiren Sun, Tobias Mutze, Richard Cook +1
Recurrent events are common and important clinical trial endpoints in many disease areas, e.g., cardiovascular hospitalizations in heart failure, relapses in multiple sclerosis, or…
Exact matching as an alternative to propensity score matching
Ekkehard Glimm, Lillian Yau
The comparison of different medical treatments from observational studies or across different clinical studies is often biased by confounding factors such as systematic differences…
Randomization-based Inference for MCP-Mod
Lukas Pin, Oleksandr Sverdlov, Frank Bretz +1
Dose selection is critical in pharmaceutical drug development, as it directly impacts therapeutic efficacy and patient safety of a drug. The Generalized Multiple Comparison Procedu…
Treatment-control comparisons in platform trials including non-concurrent controls
Marta Bofill Roig, Pavla Krotka, Katharina Hees +5
Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to t…
Beyond the classical type I error: Bayesian metrics for Bayesian designs using informative priors
Nicky Best, Maxine Ajimi, Beat Neuenschwander +2
There is growing interest in Bayesian clinical trial designs with informative prior distributions, e.g. for extrapolation of adult data to pediatrics, or use of external controls.…