3 papers
stat.AP2019
Predictively Consistent Prior Effective Sample Sizes
Beat Neuenschwander, Sebastian Weber, Heinz Schmidli +1
Determining the sample size of an experiment can be challenging, even more so when incorporating external information via a prior distribution. Such information is increasingly use…
stat.AP2019
Applying Meta-Analytic-Predictive Priors with the R Bayesian evidence synthesis tools
Sebastian Weber, Yue Li, John Seaman +2
Use of historical data in clinical trial design and analysis has shown various advantages such as reduction of within-study placebo-treated number of subjects and increase of study…
stat.AP2019
Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials
Tobias Mütze, Susanna Salem, Norbert Benda +2
Blinded sample size re-estimation and information monitoring based on blinded data has been suggested to mitigate risks due to planning uncertainties regarding nuisance parameters.…