980 citations · 3k across the 31 of their papers we have counts for
31 papers
Utilizing subgroup information in random-effects meta-analysis of few studies
Ao Huang, Christian Röver, Tim Friede
Random-effects meta-analyses are widely used for evidence synthesis in medical research. However, conventional methods based on large-sample approximations often exhibit poor perfo…
Investigating the heterogeneity of "study twins"
Christian Röver, Tim Friede
Meta-analyses are commonly performed based on random-effects models, while in certain cases one might also argue in favour of a common-effect model. One such case may be given by t…
How trace plots help interpret meta-analysis results
Christian Röver, David Rindskopf, Tim Friede
The trace plot is seldom used in meta-analysis, yet it is a very informative plot. In this article we define and illustrate what the trace plot is, and discuss why it is important.…
Using the bayesmeta R package for Bayesian random-effects meta-regression
Christian Röver, Tim Friede
BACKGROUND: Random-effects meta-analysis within a hierarchical normal modeling framework is commonly implemented in a wide range of evidence synthesis applications. More general pr…
Double arcsine transform not appropriate for meta-analysis
Christian Röver, Tim Friede
The variance-stabilizing Freeman-Tukey double arcsine transform was originally proposed for inference on single proportions. Subsequently, its use has been suggested in the context…
Summarizing empirical information on between-study heterogeneity for Bayesian random-effects meta-analysis
Christian Röver, Sibylle Sturtz, Jona Lilienthal +2
In Bayesian meta-analysis, the specification of prior probabilities for the between-study heterogeneity is commonly required, and is of particular benefit in situations where only…
A straightforward meta-analysis approach for oncology phase I dose-finding studies
Christian Röver, Moreno Ursino, Tim Friede +1
Phase I early-phase clinical studies aim at investigating the safety and the underlying dose-toxicity relationship of a drug or combination. While little may still be known about t…
On weakly informative prior distributions for the heterogeneity parameter in Bayesian random-effects meta-analysis
Christian Röver, Ralf Bender, Sofia Dias +5
The normal-normal hierarchical model (NNHM) constitutes a simple and widely used framework for meta-analysis. In the common case of only few studies contributing to the meta-analys…
Bounds for the weight of external data in shrinkage estimation
Christian Röver, Tim Friede
Shrinkage estimation in a meta-analysis framework may be used to facilitate dynamical borrowing of information. This framework might be used to analyze a new study in the light of…
Bayesian random-effects meta-analysis using the bayesmeta R package
Christian Röver
The random-effects or normal-normal hierarchical model is commonly utilized in a wide range of meta-analysis applications. A Bayesian approach to inference is very attractive in th…
Gender differences in appropriate shocks and mortality among patients with primary prophylactic implantable cardioverter-defibrillators: Systematic review and meta-analysis
David Conen, Barbora Arendacká, Christian Röver +6
BACKGROUND: Some but not all prior studies have shown that women receiving a primary prophylactic implantable cardioverter defibrillator (ICD) have a lower risk of death and approp…
Using phase II data for the analysis of phase III studies: an application in rare diseases
Simon Wandel, Beat Neuenschwander, Tim Friede +1
Clinical research and drug development in orphan diseases is challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is there…
Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases
Tim Friede, Christian Röver, Simon Wandel +1
Random-effects meta-analyses are used to combine evidence of treatment effects from multiple studies. Since treatment effects may vary across trials due to differences in study cha…
Discrete approximation of a mixture distribution via restricted divergence
Christian Röver, Tim Friede
Mixture distributions arise in many application areas, for example as marginal distributions or convolutions of distributions. We present a method of constructing an easily tractab…
Meta-analysis of few small studies in orphan diseases
Tim Friede, Christian Röver, Simon Wandel +1
Meta-analyses in orphan diseases and small populations generally face particular problems including small numbers of studies, small study sizes, and heterogeneity of results. Howev…
Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies
Christian Röver, Guido Knapp, Tim Friede
BACKGROUND: Random-effects meta-analysis is commonly performed by first deriving an estimate of the between-study variation, the heterogeneity, and subsequently using this as the b…
Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis
Nicolae-Catalin Mechie, Christian Röver, Silke Cameron +1
AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C…
Robust parameter estimation for compact binaries with ground-based gravitational-wave observations using the LALInference software library
John Veitch, Vivien Raymond, Benjamin Farr +24
The Advanced LIGO and Advanced Virgo gravitational wave (GW) detectors will begin operation in the coming years, with compact binary coalescence events a likely source for the firs…
Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies
Nicola D. Crins, Christian Röver, Armin D. Goralczyk +1
Interleukin-2 receptor antagonists (IL-2RA) are frequently used as induction therapy in liver transplant recipients to decrease the risk of acute rejection while allowing the reduc…
Reconstructing the sky location of gravitational-wave detected compact binary systems: methodology for testing and comparison
Trevor Sidery, Ben Aylott, Nelson Christensen +20
The problem of reconstructing the sky position of compact binary coalescences detected via gravitational waves is a central one for future observations with the ground-based networ…
Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data
Christian Röver, Stefan Andreas, Tim Friede
The analysis of count data is commonly done using Poisson models. Negative binomial models are a straightforward and readily motivated generalization for the case of overdispersed…
Changing EDSS progression in placebo cohorts in relapsing MS: A systematic review and meta-regression
Christian Röver, Richard Nicholas, Sebastian Straube +1
Background: Recent systematic reviews of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS) revealed a decrease in placebo annualized relapse rates (ARR) ove…
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression
Simon M. Steinvorth, Christian Röver, Simon Schneider +3
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).…
Bayesian versus frequentist upper limits
Christian Röver, Chris Messenger, Reinhard Prix
While gravitational waves have not yet been measured directly, data analysis from detection experiments commonly includes an upper limit statement. Such upper limits may be derived…