980 citations · 3k across the 31 of their papers we have counts for
5 papers · 1 filter
Gender differences in appropriate shocks and mortality among patients with primary prophylactic implantable cardioverter-defibrillators: Systematic review and meta-analysis
David Conen, Barbora Arendacká, Christian Röver +6
BACKGROUND: Some but not all prior studies have shown that women receiving a primary prophylactic implantable cardioverter defibrillator (ICD) have a lower risk of death and approp…
Using phase II data for the analysis of phase III studies: an application in rare diseases
Simon Wandel, Beat Neuenschwander, Tim Friede +1
Clinical research and drug development in orphan diseases is challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is there…
Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases
Tim Friede, Christian Röver, Simon Wandel +1
Random-effects meta-analyses are used to combine evidence of treatment effects from multiple studies. Since treatment effects may vary across trials due to differences in study cha…
Discrete approximation of a mixture distribution via restricted divergence
Christian Röver, Tim Friede
Mixture distributions arise in many application areas, for example as marginal distributions or convolutions of distributions. We present a method of constructing an easily tractab…
Meta-analysis of few small studies in orphan diseases
Tim Friede, Christian Röver, Simon Wandel +1
Meta-analyses in orphan diseases and small populations generally face particular problems including small numbers of studies, small study sizes, and heterogeneity of results. Howev…