240 citations
- Universitätsmedizin GöttingenDE13 papers
- Medical University of ViennaAT10 papers
- Roche (Switzerland)CH10 papers
- University of GöttingenDE9 papers
- Pfizer (United States)US6 papers
- Tris Pharma (United States)US6 papers
- Lancaster UniversityGB5 papers
- MRC Biostatistics UnitGB5 papers
- Novartis (United States)US5 papers
- University Hospital MagdeburgDE5 papers
- Boehringer Ingelheim (Germany)DE4 papers
- Newcastle UniversityGB4 papers
71 papers
Confidence intervals for two-stage adaptive designs with subpopulation selection
Enyu Li, Nigel Stallard, Ekkehard Glimm +2
We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs all…
Inverse Probability Weighting for Recurrent Event Models
Jiren Sun, Tobias Mutze, Richard Cook +1
Recurrent events are common and important clinical trial endpoints in many disease areas, e.g., cardiovascular hospitalizations in heart failure, relapses in multiple sclerosis, or…
Exact matching as an alternative to propensity score matching
Ekkehard Glimm, Lillian Yau
The comparison of different medical treatments from observational studies or across different clinical studies is often biased by confounding factors such as systematic differences…
In silico clinical trials in drug development: a systematic review
Bohua Chen, Lucia Chantal Schneider, Christian Röver +15
In the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of th…
Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
Konstantinos Sechidis, Cong Zhang, Sophie Sun +3
Assessing treatment effect heterogeneity (TEH) in clinical trials is crucial, as it provides insights into the variability of treatment responses among patients, influencing import…
Randomization-based Inference for MCP-Mod
Lukas Pin, Oleksandr Sverdlov, Frank Bretz +1
Dose selection is critical in pharmaceutical drug development, as it directly impacts therapeutic efficacy and patient safety of a drug. The Generalized Multiple Comparison Procedu…