activity
20162020
most citedSeamless phase II/III clinical trials using early outcomes for treatment or subgroup selection: Methods and aspects of their implementation

1 citations · 1 across the 5 of their papers we have counts for

collaborators

24 papers

stat.ME2020

Blinded sample size re-calculation in multiple composite population designs with normal data and baseline adjustments

Roland Gerard Gera, Tim Friede

The increasing interest in subpopulation analysis has led to the development of various new trial designs and analysis methods in the fields of personalized medicine and targeted t…

stat.AP2020

Design aspects of COVID-19 treatment trials: Improving probability and time of favourable events

Jan Beyersmann, Tim Friede, Claudia Schmoor

As a reaction to the pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a multitude of clinical trials for the treatment of SARS-CoV-2 or the resulting c…

cs.CY2020

Is there a role for statistics in artificial intelligence?

Sarah Friedrich, Gerd Antes, Sigrid Behr +11

The research on and application of artificial intelligence (AI) has triggered a comprehensive scientific, economic, social and political discussion. Here we argue that statistics,…

q-bio.OT2020

Data monitoring committees for clinical trials evaluating treatments of COVID-19

Tobias Mütze, Tim Friede

The first cases of coronavirus disease 2019 (COVID-19) were reported in December 2019 and the outbreak of SARS-CoV-2 was declared a pandemic in March 2020 by the World Health Organ…

stat.AP2020

Causal inference methods for small non-randomized studies: Methods and an application in COVID-19

Sarah Friedrich, Tim Friede

The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in su…

stat.ME2020

Using clinical trial registries to inform Copas selection model for publication bias in meta-analysis

Ao Huang, Sho Komukai, Tim Friede +1

Prospective registration of study protocols in clinical trial registries is a useful way to minimize the risk of publication bias in meta-analysis, and several clinical trial regis…