4 citations · 5 across the 9 of their papers we have counts for
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Design aspects of COVID-19 treatment trials: Improving probability and time of favourable events
Jan Beyersmann, Tim Friede, Claudia Schmoor
As a reaction to the pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a multitude of clinical trials for the treatment of SARS-CoV-2 or the resulting c…
Causal inference methods for small non-randomized studies: Methods and an application in COVID-19
Sarah Friedrich, Tim Friede
The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in su…
Clinical trials impacted by the COVID-19 pandemic: Adaptive designs to the rescue?
Cornelia Ursula Kunz, Silke Jörgens, Frank Bretz +6
Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the Wo…
Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules
Burak Kürsad Günhan, Paul Meyvisch, Tim Friede
Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis. If t…
Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project
M. Zabel, S. Schlögl, A. Lubinski +45
BACKGROUND. The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients…
Decline of COPD exacerbations in clinical trials over two decades -- a systematic review and meta-regression
Stefan Andreas, Christian Röver, Judith Heinz +3
BACKGROUND: An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerba…