13 citations · 15 across the 12 of their papers we have counts for
14 papers
Trial design considerations in the face of overdispersion and time-varying event rates: a meta-regression approach with an application in asthma
Bohua Chen, Christian Röver, Stefan Andreas +2
**Purpose:** Relative changes in event rates are a common primary endpoint in confirmatory asthma trials. Reliable assumptions about baseline event rates and extra-Poisson variabil…
Discussion on "Principled type I error rate inflation in two-arm clinical trial designs with external control information borrowing" by Silvia Calderazzo, Manuel Wiesenfarth, Vivienn Weru, and Annette Kopp-Schneider
Tim Friede, Christian Röver
Consideration of frequentist type-I error or power based on certain fixed conditions may not fully embrace the aims of a Bayesian analysis; this is particularly true in settings wh…
Empirical prior distributions for treatment-by-subgroup interaction heterogeneity in random-effects meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup analyses are central to the assessment of benefits and risks, where recommendations may depend on evidence that treatment effects differ across patient groups. Valid subgr…
Subgroup analysis in randomized controlled trials with binary outcomes: dilution and logic-respecting properties
Long-Hao Xu, Yang Han, Tim Friede
Subgroup analysis is routinely used in randomized controlled trials to examine whether treatment effects are homogeneous across patient subgroups or differ because of treatment-eff…
Including historical control data in simultaneous inference for pre-clinical multi-arm studies
Max Menssen, Carsten Kneuer, Gyamfi Akyianu +3
In pre- and non-clinical toxicology, the reduction of animal use is highly desireable. Although approaches for possible sample size reduction in the concurrent control group were s…
Blinded sample size re-estimation accounting for uncertainty in mid-trial estimation
Hirotada Maeda, Satoshi Hattori, Tim Friede
For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size c…
Consistent Bayesian meta-analysis on subgroup specific effects and interactions
Renato Panaro, Christian Röver, Tim Friede
Commonly, clinical trials report effects not only for the full study population but also for patient subgroups. Meta-analyses of subgroup-specific effects and treatment-by-subgroup…
Utilizing subgroup information in random-effects meta-analysis of few studies
Ao Huang, Christian Röver, Tim Friede
Random-effects meta-analyses are widely used for evidence synthesis in medical research. However, conventional methods based on large-sample approximations often exhibit poor perfo…
Subgroup comparisons within and across studies in meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and tre…
A note on blinded continuous monitoring for continuous outcomes
Long-Hao Xu, Tim Friede
Continuous monitoring is becoming more popular due to its significant benefits, including reducing sample sizes and reaching earlier conclusions. In general, it involves monitoring…
A studentized permutation test for the treatment effect in individual participant data meta-analysis
Phuc Thien Tran, Long-Hao Xu, Christian Röver +1
Meta-analysis is a well-established tool used to combine data from several independent studies, each of which usually compares the effect of an experimental treatment with a contro…
Meta-analytic-predictive priors based on a single study
Christian Röver, Tim Friede
Meta-analytic-predictive (MAP) priors have been proposed as a generic approach to deriving informative prior distributions, where external empirical data are processed to learn abo…
Bayesian random-effects meta-analysis of aggregate data on clinical events
Christian Röver, Qiong Wu, Anja Loos +1
To investigate intervention effects on rare events, meta-analysis techniques are commonly applied in order to assess the accumulated evidence. When it comes to adverse effects in c…
In silico clinical trials in drug development: a systematic review
Bohua Chen, Lucia Chantal Schneider, Christian Röver +15
In the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of th…