6 papers
Blinded sample size re-estimation accounting for uncertainty in mid-trial estimation
Hirotada Maeda, Satoshi Hattori, Tim Friede
For randomized controlled trials to be conclusive, it is important to set the target sample size accurately at the design stage. Comparing two normal populations, the sample size c…
Consistent Bayesian meta-analysis on subgroup specific effects and interactions
Renato Panaro, Christian Röver, Tim Friede
Commonly, clinical trials report effects not only for the full study population but also for patient subgroups. Meta-analyses of subgroup-specific effects and treatment-by-subgroup…
Subgroup comparisons within and across studies in meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and tre…
A note on blinded continuous monitoring for continuous outcomes
Long-Hao Xu, Tim Friede
Continuous monitoring is becoming more popular due to its significant benefits, including reducing sample sizes and reaching earlier conclusions. In general, it involves monitoring…
A studentized permutation test for the treatment effect in individual participant data meta-analysis
Phuc Thien Tran, Long-Hao Xu, Christian Röver +1
Meta-analysis is a well-established tool used to combine data from several independent studies, each of which usually compares the effect of an experimental treatment with a contro…
Meta-analytic-predictive priors based on a single study
Christian Röver, Tim Friede
Meta-analytic-predictive (MAP) priors have been proposed as a generic approach to deriving informative prior distributions, where external empirical data are processed to learn abo…