101 citations
- Novartis (Switzerland)CH5 papers
- Medical University of ViennaAT2 papers
- Université Paris CitéFR2 papers
- Assistance Publique – Hôpitaux de ParisFR1 paper
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasES1 paper
- Florida CollegeUS1 paper
- Fred Hutch Cancer CenterUS1 paper
- Indiana UniversityUS1 paper
- Infection, Anti-microbiens, Modélisation, EvolutionFR1 paper
- InsermFR1 paper
- Instituto de Salud Carlos IIIES1 paper
- Janssen (United States)US1 paper
10 papers
Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints
Elias Laurin Meyer, Peter Mesenbrink, Nicholas A. Di Prospero +5
Non-alcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and a disease with high unmet medical need. Platform trials provide great b…
Eliciting judgements about dependent quantities of interest: The SHELF extension and copula methods illustrated using an asthma case study
Björn Holzhauer, Lisa V. Hampson, John Paul Gosling +8
Pharmaceutical companies regularly need to make decisions about drug development programs based on the limited knowledge from early stage clinical trials. In this situation, elicit…
Applications of artificial intelligence in drug development using real-world data
Zhaoyi Chen, Xiong Liu, William Hogan +2
The US Food and Drug Administration (FDA) has been actively promoting the use of real-world data (RWD) in drug development. RWD can generate important real-world evidence reflectin…
Attention-Based LSTM Network for COVID-19 Clinical Trial Parsing
Xiong Liu, Luca A. Finelli, Greg L. Hersch +1
COVID-19 clinical trial design is a critical task in developing therapeutics for the prevention and treatment of COVID-19. In this study, we apply a deep learning approach to extra…
Automated transition state theory calculations for high-throughput kinetics
Pierre L. Bhoorasingh, Belinda L. Slakman, Fariba Seyedzadeh Khanshan +2
A scarcity of known chemical kinetic parameters leads to the use of many reaction rate estimates, which are not always sufficiently accurate, in the construction of detailed kineti…
Optimal exact tests for multiple binary endpoints
Robin Ristl, Dong Xi, Ekkehard Glimm +1
In confirmatory clinical trials with small sample sizes, hypothesis tests based on asymptotic distributions are often not valid and exact non-parametric procedures are applied inst…