3 papers
stat.ME2020
A Bayesian time-to-event pharmacokinetic model for phase I dose-escalation trials with multiple schedules
Burak Kürsad Günhan, Sebastian Weber, Tim Friede
Phase I dose-escalation trials must be guided by a safety model in order to avoid exposing patients to unacceptably high risk of toxicities. Traditionally, these trials are based o…
stat.AP2019
Predictively Consistent Prior Effective Sample Sizes
Beat Neuenschwander, Sebastian Weber, Heinz Schmidli +1
Determining the sample size of an experiment can be challenging, even more so when incorporating external information via a prior distribution. Such information is increasingly use…
stat.AP2019
Applying Meta-Analytic-Predictive Priors with the R Bayesian evidence synthesis tools
Sebastian Weber, Yue Li, John Seaman +2
Use of historical data in clinical trial design and analysis has shown various advantages such as reduction of within-study placebo-treated number of subjects and increase of study…