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stat.AP2019
Predictively Consistent Prior Effective Sample Sizes
Beat Neuenschwander, Sebastian Weber, Heinz Schmidli +1
Determining the sample size of an experiment can be challenging, even more so when incorporating external information via a prior distribution. Such information is increasingly use…
stat.AP2019
Applying Meta-Analytic-Predictive Priors with the R Bayesian evidence synthesis tools
Sebastian Weber, Yue Li, John Seaman +2
Use of historical data in clinical trial design and analysis has shown various advantages such as reduction of within-study placebo-treated number of subjects and increase of study…
stat.AP2018
A Bayesian time-to-event pharmacokinetic model for sequential phase I dose-escalation trials with multiple schedules
Burak Kürsad Günhan, Sebastian Weber, Abdelkader Seroutou +1
Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation tria…