338 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- The University of Texas MD Anderson Cancer CenterUS17 papers
- The University of Texas Health Science CenterUS15 papers
- Yale UniversityUS13 papers
- Rice UniversityUS12 papers
- Fudan UniversityCN7 papers
- Harvard UniversityUS7 papers
- Mayo Clinic in FloridaUS7 papers
- National Institutes of HealthUS6 papers
- University of PennsylvaniaUS6 papers
- Texas A&M UniversityUS5 papers
- Baylor College of MedicineUS4 papers
- Cornell UniversityUS4 papers
12 papers · 1 filter
KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation
L Cif, D Demailly, JP Lin +112
Heterozygous mutations in KMT2B are associated with an early-onset, progressive, and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor feat…
Discriminative Sleep Patterns of Alzheimer's Disease via Tensor Factorization
Yejin Kim, Xiaoqian Jiang, Luyao Chen +2
Sleep change is commonly reported in Alzheimer's disease (AD) patients and their brain wave studies show decrease in dreaming and non-dreaming stages. Although sleep disturbance is…
Deep Learning for Quality Control of Subcortical Brain 3D Shape Models
Dmitry Petrov, Boris A. Gutman Egor Kuznetsov, Theo G. M. van Erp +70
We present several deep learning models for assessing the morphometric fidelity of deep grey matter region models extracted from brain MRI. We test three different convolutional ne…
Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal
Paul Smolen, Douglas A. Baxter, John H. Byrne
The transition from early long-term potentiation (E-LTP) to late LTP (L-LTP) involves protein synthesis and degradation. L-LTP is blocked by inhibiting either protein synthesis or…
Mutual Information in Frequency and its Application to Measure Cross-Frequency Coupling in Epilepsy
Rakesh Malladi, Don H Johnson, Giridhar P Kalamangalam +2
We define a metric, mutual information in frequency (MI-in-frequency), to detect and quantify the statistical dependence between different frequency components in the data, referre…
The right time to learn: mechanisms and optimization of spaced learning
Paul Smolen, Yili Zhang, John H. Byrne
For many types of learning, spaced training that involves repeated long inter-trial intervals (ITIs) leads to more robust memory formation than does massed training that involves s…
Identifying Seizure Onset Zone from the Causal Connectivity Inferred Using Directed Information
Rakesh Malladi, Giridhar Kalamangalam, Nitin Tandon +1
In this paper, we developed a model-based and a data-driven estimator for directed information (DI) to infer the causal connectivity graph between electrocorticographic (ECoG) sign…
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability
Paul Smolen
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist? Some model…
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation
Paul Smolen, Douglas A. Baxter, John H. Byrne
Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a m…
Molecular Constraints on Synaptic Tagging and Maintenance of Long-Term Potentiation: A Predictive Model
Paul Smolen, Douglas A. Baxter, John H. Byrne
Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plas…
A Model of Late Long-Term Potentiation Simulates Aspects of Memory Maintenance
Paul Smolen
Late long-term potentiation (L-LTP) appears essential for the formation of long-term memory, with memories at least partly encoded by patterns of strengthened synapses. How memorie…
A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation
Paul Smolen, Douglas A. Baxter, John H. Byrne
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model w…