307 citations · 581 across the 11 of their papers we have counts for
11 papers
Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways
Paul Smolen, Douglas A Baxter, John H Byrne
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharma…
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation
Paul Smolen, Douglas A. Baxter, John H. Byrne
How can memories be maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP)? One likely solution relies on…
How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory
Paul Smolen, Douglas A. Baxter, John H. Byrne
With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular…
Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal
Paul Smolen, Douglas A. Baxter, John H. Byrne
The transition from early long-term potentiation (E-LTP) to late LTP (L-LTP) involves protein synthesis and degradation. L-LTP is blocked by inhibiting either protein synthesis or…
The right time to learn: mechanisms and optimization of spaced learning
Paul Smolen, Yili Zhang, John H. Byrne
For many types of learning, spaced training that involves repeated long inter-trial intervals (ITIs) leads to more robust memory formation than does massed training that involves s…
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation
Paul Smolen, Douglas A. Baxter, John H. Byrne
Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a m…