307 citations · 612 across the 13 of their papers we have counts for
13 papers
Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways
Paul Smolen, Douglas A Baxter, John H Byrne
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharma…
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation
Paul Smolen, Douglas A. Baxter, John H. Byrne
How can memories be maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP)? One likely solution relies on…
How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory
Paul Smolen, Douglas A. Baxter, John H. Byrne
With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular…
Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal
Paul Smolen, Douglas A. Baxter, John H. Byrne
The transition from early long-term potentiation (E-LTP) to late LTP (L-LTP) involves protein synthesis and degradation. L-LTP is blocked by inhibiting either protein synthesis or…
The right time to learn: mechanisms and optimization of spaced learning
Paul Smolen, Yili Zhang, John H. Byrne
For many types of learning, spaced training that involves repeated long inter-trial intervals (ITIs) leads to more robust memory formation than does massed training that involves s…
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability
Paul Smolen
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist? Some model…