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q-bio.MN2012
Interlinked Dual-Time Feedback Loops can Enhance Robustness to Stochasticity and Persistence of Memory
Paul Smolen, Douglas A. Baxter, John H. Byrne
Multiple interlinked positive feedback loops shape the stimulus responses of various biochemical systems, such as the cell cycle or intracellular calcium release. Recent studies wi…
q-bio.MN2008
Bistable MAP Kinase Activity: A Plausible Mechanism Contributing to Maintenance of Late Long-Term Potentiation
Paul Smolen, Douglas A. Baxter, John H. Byrne
Bistability of MAP kinase (MAPK) activity has been suggested to contribute to several cellular processes, including differentiation and long-term synaptic potentiation. A recent mo…
q-bio.MN2004
Simulation of Drosophila Circadian Oscillations, Mutations, and Light Responses by a Model with VRI, PDP-1, and CLK
Paul Smolen, Paul E. Hardin, Brian S. Lo +2
A model of Drosophila circadian rhythm generation was developed to represent feedback loops based on transcriptional regulation of per, Clk (dclock), Pdp-1, and vri (vrille). The m…