82 citations · 274 across the 10 of their papers we have counts for
10 papers
Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways
Paul Smolen, Douglas A Baxter, John H Byrne
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharma…
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation
Paul Smolen, Douglas A. Baxter, John H. Byrne
How can memories be maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP)? One likely solution relies on…
How Can Memories Last for Days, Years, or a Lifetime? Proposed Mechanisms for Maintaining Synaptic Potentiation and Memory
Paul Smolen, Douglas A. Baxter, John H. Byrne
With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular…
Paradoxical LTP maintenance with inhibition of protein synthesis and the proteasome suggests a novel protein synthesis requirement for early LTP reversal
Paul Smolen, Douglas A. Baxter, John H. Byrne
The transition from early long-term potentiation (E-LTP) to late LTP (L-LTP) involves protein synthesis and degradation. L-LTP is blocked by inhibiting either protein synthesis or…
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation
Paul Smolen, Douglas A. Baxter, John H. Byrne
Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a m…
Interlinked Dual-Time Feedback Loops can Enhance Robustness to Stochasticity and Persistence of Memory
Paul Smolen, Douglas A. Baxter, John H. Byrne
Multiple interlinked positive feedback loops shape the stimulus responses of various biochemical systems, such as the cell cycle or intracellular calcium release. Recent studies wi…