883 citations
2 papers
q-bio.MN2005★ 16 cited
A p53 Oscillator Model of DNA Break Repair Control
Vijay Chickarmane, Ali Nadim, Animesh Ray +1
The transcription factor p53 is an important regulator of cell fate. Mutations in p53 gene are associated with many cancers. In response to signals such as DNA damage, p53 controls…
q-bio.PE2005★ 883 cited
Why highly expressed proteins evolve slowly
D. Allan Drummond, Jesse D. Bloom, Christoph Adami +2
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, f…