17 citations · 23 across the 5 of their papers we have counts for
6 papers
A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntington's disease
B. Patra, Y. Kon, G. Yadav +17
Mutational robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of mutational robustness in the buddi…
Trade-offs drive resource specialization and the gradual establishment of ecotypes
Bjørn Østman, Randall Lin, Christoph Adami
Speciation is driven by many different factors. Among those are trade-offs between different ways an organism utilizes resources, and these trade-offs can constrain the manner in w…
Effects of Epistasis and Pleiotropy on Fitness Landscapes
Bjørn Østman
The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is use…
Predicting evolution and visualizing high-dimensional fitness landscapes
Bjørn Østman, Christoph Adami
The tempo and mode of an adaptive process is strongly determined by the structure of the fitness landscape that underlies it. In order to be able to predict evolutionary outcomes (…
Critical properties of complex fitness landscapes
Bjørn Østman, Arend Hintze, Christoph Adami
Evolutionary adaptation is the process that increases the fit of a population to the fitness landscape it inhabits. As a consequence, evolutionary dynamics is shaped, constrained,…
Impact of Epistasis and Pleiotropy on Evolutionary Adaptation
Bjørn Østman, Arend Hintze, Christoph Adami
Evolutionary adaptation is often likened to climbing a hill or peak. While this process is simple for fitness landscapes where mutations are independent, the interaction between mu…