359 citations · 359 across the 2 of their papers we have counts for
2 papers
q-bio.PE2005
Population genetics of translational robustness
Claus O. Wilke, D. Allan Drummond
Recent work has shown that expression level is the main predictor of a gene’s evolutionary rate, and that more highly expressed genes evolve slower. A possible explanation fo…
q-bio.BM2004★ 359 cited
Thermodynamic Prediction of Protein Neutrality
Jesse D. Bloom, Jonathan J. Silberg, Claus O. Wilke +3
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wildtype structure after one or more random amino acid substitut…