883 citations · 2.1k across the 4 of their papers we have counts for
3 papers
Population genetics of translational robustness
Claus O. Wilke, D. Allan Drummond
Recent work has shown that expression level is the main predictor of a gene’s evolutionary rate, and that more highly expressed genes evolve slower. A possible explanation fo…
Why highly expressed proteins evolve slowly
D. Allan Drummond, Jesse D. Bloom, Christoph Adami +2
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, f…
Thermodynamic Prediction of Protein Neutrality
Jesse D. Bloom, Jonathan J. Silberg, Claus O. Wilke +3
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wildtype structure after one or more random amino acid substitut…