2 papers
q-bio.BM2026
StabilityArc: Decoding Protein Sequence Embeddings into Generalizable Stability Landscapes
Aaron L. Feller, Andrew D. Ellington, Claus O. Wilke
Every protein has a unique stability landscape, but the physical consequences of mutation are governed by recurring biochemical constraints. We test whether a shared decoder, train…
q-bio.QM2023
Mining Patents with Large Language Models Elucidates the Chemical Function Landscape
Clayton W. Kosonocky, Claus O. Wilke, Edward M. Marcotte +1
The fundamental goal of small molecule discovery is to generate chemicals with target functionality. While this often proceeds through structure-based methods, we set out to invest…