883 citations · 885 across the 4 of their papers we have counts for
4 papers
Population genetics of translational robustness
Claus O. Wilke, D. Allan Drummond
Recent work has shown that expression level is the main predictor of a gene’s evolutionary rate, and that more highly expressed genes evolve slower. A possible explanation fo…
Quasispecies can exist under neutral drift at finite population sizes
Robert Forster, Christoph Adami, Claus O. Wilke
We investigate the evolutionary dynamics of a finite population of RNA sequences adapting to a neutral fitness landscape. Despite the lack of differential fitness between viable se…
A single determinant for the rate of yeast protein evolution
D. Allan Drummond, Alpan Raval, Claus O. Wilke
A gene's rate of sequence evolution is among the most fundamental evolutionary quantities in common use, but what determines evolutionary rates has remained unclear. Here, we show…
Why highly expressed proteins evolve slowly
D. Allan Drummond, Jesse D. Bloom, Christoph Adami +2
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, f…