44 citations
- University of EdinburghGB14 papers
- Edinburgh Cancer ResearchGB4 papers
- University of BathGB3 papers
- Istituto Nazionale di Fisica Nucleare, Sezione di PadovaIT2 papers
- University of PaduaIT2 papers
- Aoyama Gakuin UniversityJP1 paper
- Hiroshima International UniversityJP1 paper
- Institute of Science and Technology AustriaAT1 paper
- Japan Science and Technology AgencyJP1 paper
- Laboratoire de Physique Théorique et Modèles StatistiquesFR1 paper
- MRC Human Genetics Unit1 paper
- National Institute of Advanced Industrial Science and TechnologyJP1 paper
14 papers
Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA
Filippo Conforto, Antonio Valdes, Willem Vanderlinden +1
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins organise the folding of chromosomes. However, their role in modulating the entanglement of DNA and chromatin…
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Michael Chiang, Cleis Battaglia, Giada Forte +3
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we…
Topological Linking Determines Elasticity in Limited Valence Networks
Giorgia Palombo, Simon Weir, Davide Michieletto +1
Understanding the relationship between the microscopic structure and topology of a material and its macroscopic properties is a fundamental challenge across a wide range of systems…
Effects of Monovalent and Divalent Cations on the Rheology of Entangled DNA
Jennifer Harnett, Simon Weir, Davide Michieletto
In this paper we investigate the effects of varying cation valency and concentration on the rheology of entangled lambda DNA solutions. We show that monovalent cations moderately i…
Geometric Learning of Knot Topology
Joseph Lahoud Sleiman, Filippo Conforto, Yair Augusto Gutierrez Fosado +1
Knots are deeply entangled with every branch of science. One of the biggest open challenges in knot theory is to formalise a knot invariant that can unambiguously and efficiently d…
Discrete fragmentation equations with time-dependent coefficients
Lyndsay Kerr, Wilson Lamb, Matthias Langer
We examine an infinite, linear system of ordinary differential equations that models the evolution of fragmenting clusters, where each cluster is assumed to be composed of identica…