32 citations · 65 across the 11 of their papers we have counts for
12 papers
Functional understanding of structural components in polypseudorotaxane gels
Ella Sapsford, Andrea Bonato, Simon Weir +4
Biomedical devices, wearable interfaces, and soft robots require compliant soft materials with reliable mechanical performance, yet the molecular principles needed to design such m…
NANOG assembles into self-limiting aging micelles that drive a sol-gel transition and modulate DNA dynamics
Amandine Hong-Minh, Yair Augusto Gutierrez Fosado, Abbie Guild +4
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcr…
Rheology and Programmable Gelation of DNA Origami Polymer Tadpoles
Jennifer Harnett, Saminathan Ramakrishnan, Alice L. B. Pyne +2
DNA origami is a powerful method to achieve nanoscale folded structures. Despite rapid improvements in folding and purification methods, DNA origami objects are still often produce…
Designing DNA nanostar hydrogels with programmable degradation and antibody release
Giorgia Palombo, Christine A. Merrick, Jennifer Harnett +3
DNA nanostar (DNAns) hydrogels are promising materials for \textit{in vivo} applications, including tissue regeneration and drug and antibody delivery. However, a systematic and qu…
Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities
Cleis Battaglia, Filippo Conforto, Yair Augusto Gutierrez Fosado +4
Type II Topoisomerases (topo II) are critical to simplify genome topology during transcription and replication. They identify topological problems and resolve them by passing a dou…
Modulation of DNA rheology by a transcription factor that forms aging microgels
Amandine Hong-Minh, Yair Augusto Gutiérrez Fosado, Abbie Guild +4
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcr…
Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA
Filippo Conforto, Antonio Valdes, Willem Vanderlinden +1
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins organise the folding of chromosomes. However, their role in modulating the entanglement of DNA and chromatin…
Fluidification of Entangled Polymers by Loop Extrusion
Filippo Conforto, Yair Augusto Gutierrez Fosado, Davide Michieletto
Loop extrusion is one of the main processes shaping chromosome organisation across the cell cycle, yet its role in regulating DNA entanglement and nucleoplasm viscoelasticity remai…
Topological Linking Determines Elasticity in Limited Valence Networks
Giorgia Palombo, Simon Weir, Davide Michieletto +1
Understanding the relationship between the microscopic structure and topology of a material and its macroscopic properties is a fundamental challenge across a wide range of systems…
Effects of Monovalent and Divalent Cations on the Rheology of Entangled DNA
Jennifer Harnett, Simon Weir, Davide Michieletto
In this paper we investigate the effects of varying cation valency and concentration on the rheology of entangled lambda DNA solutions. We show that monovalent cations moderately i…
Runaway Transition in Irreversible Polymer Condensation with Cyclisation
Maria Panoukidou, Simon Weir, Valerio Sorichetti +3
The process of polymer condensation, i.e. the formation of bonds between reactive end-groups, is ubiquitous in both industry and biology. Here we study generic systems undergoing p…
Topological digestion drives time-varying rheology of entangled DNA fluids
Davide Michieletto, Philip Neill, Simon Weir +4
Understanding and controlling the rheology of polymeric complex fluids that are pushed out-of-equilibrium is a fundamental problem in both industry and biology. For example, to pac…