3 papers
physics.bio-ph2025
Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities
Cleis Battaglia, Filippo Conforto, Yair Augusto Gutierrez Fosado +4
Type II Topoisomerases (topo II) are critical to simplify genome topology during transcription and replication. They identify topological problems and resolve them by passing a dou…
cond-mat.soft2025
Modulation of DNA rheology by a transcription factor that forms aging microgels
Amandine Hong-Minh, Yair Augusto Gutiérrez Fosado, Abbie Guild +4
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcr…
cond-mat.soft2025
Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA
Filippo Conforto, Antonio Valdes, Willem Vanderlinden +1
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins organise the folding of chromosomes. However, their role in modulating the entanglement of DNA and chromatin…