916 citations
- Eötvös Loránd UniversityHU20 papers
- Hungarian Academy of SciencesHU11 papers
- Budapest University of Technology and EconomicsHU10 papers
- HUN-REN Wigner Research Centre for PhysicsHU7 papers
- Institute for Solid State Physics and OpticsHU6 papers
- Pázmány Péter Catholic UniversityHU4 papers
- Tel Aviv UniversityIL4 papers
- University of DebrecenHU4 papers
- Center for Cancer ResearchUS3 papers
- Earlham InstituteGB3 papers
- HUN-REN Research Centre for Natural SciencesHU3 papers
- HUN-REN Szegedi Biológiai KutatóközpontHU3 papers
Showing 2004Show all
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q-bio.MN2004★ 813 cited
The efficiency of multi-target drugs: the network approach might help drug design
Peter Csermely, Vilmos Agoston, Sandor Pongor
Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increas…
q-bio.MN2004★ 111 cited
Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
Vilmos Agoston, Peter Csermely, Sandor Pongor
Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening o…
q-bio.BM2004★ 67 cited
Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins
Istvan A. Kovacs, Mate S. Szalay, Peter Csermely
Water molecules and molecular chaperones efficiently help the protein folding process. Here we describe their action in the context of the energy and topological networks of protei…