86 citations · 248 across the 6 of their papers we have counts for
6 papers
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
Robin Palotai, Mate S. Szalay, Peter Csermely
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the cen…
Network analysis of protein dynamics
Csaba Bode, Istvan A. Kovacs, Mate S. Szalay +3
The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here we review the results of the topological analysis of protein structures as…
How to design multi-target drugs: Target search options in cellular networks
Tamas Korcsmaros, Mate S. Szalay, Csaba Bode +2
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behi…
Stress-induced rearrangements of cellular networks: consequences for protection and drug design
Mate S. Szalay, Istvan A. Kovacs, Tamas Korcsmaros +2
The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and…
Molecular chaperones: The modular evolution of cellular networks
Tamas Korcsmaros, Istvan A. Kovacs, Mate S. Szalay +1
Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabil…
Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins
Istvan A. Kovacs, Mate S. Szalay, Peter Csermely
Water molecules and molecular chaperones efficiently help the protein folding process. Here we describe their action in the context of the energy and topological networks of protei…