342 citations · 888 across the 9 of their papers we have counts for
9 papers
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
Tamas Korcsmaros, Illes J. Farkas, Maté S. Szalay +7
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different le…
Community landscapes: an integrative approach to determine overlapping network module hierarchy, identify key nodes and predict network dynamics
Istvan A. Kovacs, Robin Palotai, Mate S. Szalay +1
Background: Network communities help the functional organization and evolution of complex networks. However, the development of a method, which is both fast and accurate, provides…
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
Robin Palotai, Mate S. Szalay, Peter Csermely
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the cen…
Learning and innovative elements of strategy adoption rules expand cooperative network topologies
Shijun Wang, Mate S. Szalay, Changshui Zhang +1
Cooperation plays a key role in the evolution of complex systems. However, the level of cooperation extensively varies with the topology of agent networks in the widely used models…
Network analysis of protein dynamics
Csaba Bode, Istvan A. Kovacs, Mate S. Szalay +3
The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here we review the results of the topological analysis of protein structures as…
How to design multi-target drugs: Target search options in cellular networks
Tamas Korcsmaros, Mate S. Szalay, Csaba Bode +2
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behi…