342 citations · 888 across the 9 of their papers we have counts for
6 papers · 1 filter
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
Tamas Korcsmaros, Illes J. Farkas, Maté S. Szalay +7
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different le…
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
Robin Palotai, Mate S. Szalay, Peter Csermely
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the cen…
Learning and innovative elements of strategy adoption rules expand cooperative network topologies
Shijun Wang, Mate S. Szalay, Changshui Zhang +1
Cooperation plays a key role in the evolution of complex systems. However, the level of cooperation extensively varies with the topology of agent networks in the widely used models…
How to design multi-target drugs: Target search options in cellular networks
Tamas Korcsmaros, Mate S. Szalay, Csaba Bode +2
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behi…
Stress-induced rearrangements of cellular networks: consequences for protection and drug design
Mate S. Szalay, Istvan A. Kovacs, Tamas Korcsmaros +2
The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and…
Molecular chaperones: The modular evolution of cellular networks
Tamas Korcsmaros, Istvan A. Kovacs, Mate S. Szalay +1
Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabil…