916 citations · 1.4k across the 10 of their papers we have counts for
10 papers
Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations
Aron R. Perez-Lopez, Kristof Z. Szalay, Denes Turei +4
Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread pertur…
ComPPI, a cellular compartment-specific database for protein-protein interaction network analysis
Daniel V. Veres, David M. Gyurko, Benedek Thaler +4
Here we present ComPPI, a cellular compartment specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network ana…
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism
Peter Csermely, Janos Hodsagi, Tamas Korcsmaros +7
Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial incre…
Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies
David M. Gyurko, Daniel V. Veres, Dezso Modos +3
There is a widening recognition that cancer cells are products of complex developmental processes. Carcinogenesis and metastasis formation are increasingly described as systems-lev…
Structure and dynamics of molecular networks: A novel paradigm of drug discovery. A comprehensive review
Peter Csermely, Tamas Korcsmaros, Huba J. M. Kiss +2
Despite considerable progress in genome- and proteome-based high-throughput screening methods and in rational drug design, the increase in approved drugs in the past decade did not…
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
Tamas Korcsmaros, Illes J. Farkas, Maté S. Szalay +7
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different le…