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q-bio.MN2004★ 813 cited
The efficiency of multi-target drugs: the network approach might help drug design
Peter Csermely, Vilmos Agoston, Sandor Pongor
Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increas…
q-bio.MN2004★ 111 cited
Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example
Vilmos Agoston, Peter Csermely, Sandor Pongor
Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening o…