742 citations
- Wellcome TrustGB18 papers
- University of CambridgeGB11 papers
- Wellcome Sanger InstituteGB11 papers
- Centre National de la Recherche ScientifiqueFR10 papers
- Harvard UniversityUS9 papers
- SIB Swiss Institute of BioinformaticsCH9 papers
- European Molecular Biology LaboratoryDE7 papers
- Lawrence Berkeley National LaboratoryUS7 papers
- Stanford UniversityUS7 papers
- University of ManchesterGB7 papers
- Broad InstituteUS6 papers
- University of HelsinkiFI6 papers
6 papers · 1 filter
Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model
Ranjita Dutta Roy, Christian Rosenmund, Stuart J Edelstein +1
Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms behind synaptic plasticity in the central nervous system of ver…
One file to share them all: Using the COMBINE Archive and the OMEX format to share all information about a modeling project
Frank T. Bergmann, Richard Adams, Stuart Moodie +15
Background: With the ever increasing use of computational models in the biosciences, the need to share models and reproduce the results of published studies efficiently and easily…
Conservation and losses of avian non-coding RNA loci
Paul P. Gardner, Mario Fasold, Sarah W. Burge +6
Here we present the results of a large-scale bioinformatic annotation of non-coding RNA loci in 48 avian genomes. Our approach uses probabilistic models of hand-curated families fr…
Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions
Massimo Lai, Denis Brun, Stuart J Edelstein +1
Calmodulin, the ubiquitous calcium-activated second messenger in eukaryotes, is an extremely versatile molecule involved in many biological processes: muscular contraction, synapti…
Testing the Mean Matrix in High-Dimensional Transposable Data
Anestis Touloumis, Simon Tavaré, John C. Marioni
The structural information in high-dimensional transposable data allows us to write the data recorded for each subject in a matrix such that both the rows and the columns correspon…
Toward computational cumulative biology by combining models of biological datasets
Ali Faisal, Jaakko Peltonen, Elisabeth Georgii +2
A main challenge of data-driven sciences is how to make maximal use of the progressively expanding databases of experimental datasets in order to keep research cumulative. We intro…