742 citations
- Wellcome TrustGB18 papers
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13 papers · 1 filter
SBMLtoOdin and Menelmacar: Interactive visualisation of systems biology models for expert and non-expert audiences
Leonie J. Lorenz, Antoine Andréoletti, Tung V. N. Nguyen +4
Motivation: Computational models in biology can increase our understanding of biological systems, be used to answer research questions, and make predictions. Accessibility and reus…
Creation and unification of development and life stage ontologies for animals
Anne Niknejad, Christopher J. Mungall, David Osumi-Sutherland +2
With the new era of genomics, an increasing number of animal species are amenable to large-scale data generation. This had led to the emergence of new multi-species ontologies to a…
Concepts and Applications of Conformal Prediction in Computational Drug Discovery
Isidro Cortés-Ciriano, Andreas Bender
Estimating the reliability of individual predictions is key to increase the adoption of computational models and artificial intelligence in preclinical drug discovery, as well as t…
TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations
Haiming Tang, Robert D Finn, Paul D Thomas
Summary: TreeGrafter is a new software tool for annotating protein sequences using annotated phylogenetic trees. Cur-rently, the tool provides annotations to Gene Ontology terms, a…
Public archives for biological image data
Jan Ellenberg, Jason R Swedlow, Mary Barlow +4
Public data archives are the backbone of modern biological and biomedical research. While archives for biological molecules and structures are well-established, resources for imagi…
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Yuxiang Jiang, Tal Ronnen Oron, Wyatt T Clark +144
Background: The increasing volume and variety of genotypic and phenotypic data is a major defining characteristic of modern biomedical sciences. At the same time, the limitations i…