742 citations
- Wellcome TrustGB18 papers
- University of CambridgeGB11 papers
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- Centre National de la Recherche ScientifiqueFR10 papers
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4 papers · 1 filter
Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model
Ranjita Dutta Roy, Christian Rosenmund, Stuart J Edelstein +1
Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms behind synaptic plasticity in the central nervous system of ver…
Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions
Massimo Lai, Denis Brun, Stuart J Edelstein +1
Calmodulin, the ubiquitous calcium-activated second messenger in eukaryotes, is an extremely versatile molecule involved in many biological processes: muscular contraction, synapti…
SBML Qualitative Models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools
Claudine Chaouiya, Duncan Berenguier, Sarah M Keating +21
Background: Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage o…
Large-scale generation of computational models from biochemical pathway maps
Finja Büchel, Nicolas Rodriguez, Neil Swainston +23
Background: Systems biology projects and omics technologies have led to a growing number of biochemical pathway reconstructions. However, mathematical models are still most often c…