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20102026
most citedDirect-coupling analysis of residue co-evolution captures native contacts across many protein families

1.6k citations

Showing 2017Show all

12 papers · 1 filter

cs.DS2017★ 2 cited

The cavity approach for Steiner trees packing problems

Alfredo Braunstein, Anna Paola Muntoni

The Belief Propagation approximation, or cavity method, has been recently applied to several combinatorial optimization problems in its zero-temperature implementation, the max-sum…

q-bio.QM2017★ 23 cited

Initial cell density encodes proliferative potential in cancer cell populations

Chiara Enrico Bena, Marco Del Giudice, Alice Grob +8

Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the grow…

cond-mat.dis-nn2017★ 22 cited

On the role of synaptic stochasticity in training low-precision neural networks

Carlo Baldassi, Federica Gerace, Hilbert J. Kappen +4

Stochasticity and limited precision of synaptic weights in neural network models are key aspects of both biological and hardware modeling of learning processes. Here we show that a…

q-bio.MN2017★ 6 cited

Statistics of optimal information flow in ensembles of regulatory motifs

Andrea Crisanti, Andrea De Martino, Jonathan Fiorentino

Genetic regulatory circuits universally cope with different sources of noise that limit their ability to coordinate input and output signals. In many cases, optimal regulatory perf…

physics.data-an2017★ 7 cited

Improved Pseudolikelihood Regularization and Decimation methods on Non-linearly Interacting Systems with Continuous Variables

Alessia Marruzzo, Payal Tyagi, Fabrizio Antenucci +2

We propose and test improvements to state-of-the-art techniques of Bayeasian statistical inference based on pseudolikelihood maximization with regularization and with deci…

cond-mat.dis-nn2017★ 27 cited

Loop expansion around the Bethe approximation through the -layer construction

Ada Altieri, Maria Chiara Angelini, Carlo Lucibello +3

For every physical model defined on a generic graph or factor graph, the Bethe -layer construction allows building a different model for which the Bethe approximation is exact i…

q-bio.MN2017★ 2 cited

Constraint-based inverse modeling of metabolic networks: a proof of concept

Daniele De Martino, Andrea De Martino

We consider the problem of inferring the probability distribution of flux configurations in metabolic network models from empirical flux data. For the simple case in which experime…

q-bio.MN2017★ 28 cited

ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins

Araks Martirosyan, Andrea De Martino, Andrea Pagnani +1

Gene expression is a noisy process and several mechanisms, both transcriptional and posttranscriptional, can stabilize protein levels in cells. Much work has focused on the role of…

q-bio.MN2017★ 22 cited

Quantifying the entropic cost of cellular growth control

Daniele De Martino, Fabrizio Capuani, Andrea De Martino

We quantify the amount of regulation required to control growth in living cells by a Maximum Entropy approach to the space of underlying metabolic states described by genome-scale…

physics.bio-ph2017★ 36 cited

An analytic approximation of the feasible space of metabolic networks

Alfredo Braunstein, Anna Paola Muntoni, Andrea Pagnani

Assuming a steady-state condition within a cell, metabolic fluxes satisfy an under-determined linear system of stoichiometric equations. Characterizing the space of fluxes that sat…

q-bio.MN2017★ 7 cited

Translating ceRNA susceptibilities into correlation functions

Araks Martirosyan, Matteo Marsili, Andrea De Martino

Competition to bind microRNAs induces an effective positive crosstalk between their targets, therefore known as `competing endogenous RNAs' or ceRNAs. While such an effect is known…

q-bio.MN2017★ 8 cited

Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype

Jorge Fernandez-de-Cossio-Diaz, Andrea De Martino, Roberto Mulet

We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient…