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20102026
most citedDirect-coupling analysis of residue co-evolution captures native contacts across many protein families

1.6k citations

Showing 2011Show all

9 papers · 1 filter

physics.bio-ph2011★ 17 cited

Effects of confinement on thermal stability and folding kinetics in a simple Ising-like model

Michele Caraglio, Alessandro Pelizzola

In cellular environment, confinement and macromulecular crowding play an important role on thermal stability and folding kinetics of a protein. We have resorted to a generalized ve…

q-bio.QM2011★ 1.6k cited

Direct-coupling analysis of residue co-evolution captures native contacts across many protein families

Faruck Morcos, Andrea Pagnani, Bryan Lunt +7

The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting co…

cond-mat.stat-mech2011★ 16 cited

Stochastic optimization by message passing

Fabrizio Altarelli, Alfredo Braunstein, Abolfazl Ramezanpour +1

Most optimization problems in applied sciences realistically involve uncertainty in the parameters defining the cost function, of which only statistical information is known before…

cs.IT2011★ 9 cited

Efficient data compression from statistical physics of codes over finite fields

Alfredo Braunstein, Farbod Kayhan, Riccardo Zecchina

In this paper we discuss a novel data compression technique for binary symmetric sources based on the cavity method over a Galois Field of order q (GF(q)). We present a scheme of l…

cond-mat.stat-mech2011★ 26 cited

The stochastic matching problem

Fabrizio Altarelli, Alfredo Braunstein, Abolfazl Ramezanpour +1

The matching problem plays a basic role in combinatorial optimization and in statistical mechanics. In its stochastic variants, optimization decisions have to be taken given only s…

q-bio.MN2011★ 101 cited

Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks

Andrea Procaccini, Bryan Lunt, Hendrik Szurmant +2

Predictive understanding of the myriads of signal transduction pathways in a cell is an outstanding challenge of systems biology. Such pathways are primarily mediated by specific b…

cond-mat.stat-mech2011★ 5 cited

Palette-colouring: a belief-propagation approach

Alessandro Pelizzola, Marco Pretti, Jort van Mourik

We consider a variation of the prototype combinatorial-optimisation problem known as graph-colouring. Our optimisation goal is to colour the vertices of a graph with a fixed number…

cond-mat.dis-nn2011★ 18 cited

Inference and learning in sparse systems with multiple states

A. Braunstein, A. Ramezanpour, R. Zecchina +1

We discuss how inference can be performed when data are sampled from the non-ergodic phase of systems with multiple attractors. We take as model system the finite connectivity Hopf…

q-bio.MN2011★ 128 cited

Finding undetected protein associations in cell signaling by belief propagation

M. Bailly-Bechet, C. Borgs, A. Braunstein +4

External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes. High…