output
20102026
most citedDirect-coupling analysis of residue co-evolution captures native contacts across many protein families

1.6k citations

Showing 2015Show all

8 papers · 1 filter

q-bio.QM2015★ 69 cited

Inter-protein sequence co-evolution predicts known physical interactions in bacterial ribosomes and the trp operon

Christoph Feinauer, Hendrik Szurmant, Martin Weigt +1

Interaction between proteins is a fundamental mechanism that underlies virtually all biological processes. Many important interactions are conserved across a large variety of speci…

cond-mat.dis-nn2015★ 59 cited

Local entropy as a measure for sampling solutions in Constraint Satisfaction Problems

Carlo Baldassi, Alessandro Ingrosso, Carlo Lucibello +2

We introduce a novel Entropy-driven Monte Carlo (EdMC) strategy to efficiently sample solutions of random Constraint Satisfaction Problems (CSPs). First, we extend a recent result…

cond-mat.dis-nn2015★ 126 cited

Subdominant Dense Clusters Allow for Simple Learning and High Computational Performance in Neural Networks with Discrete Synapses

Carlo Baldassi, Alessandro Ingrosso, Carlo Lucibello +2

We show that discrete synaptic weights can be efficiently used for learning in large scale neural systems, and lead to unanticipated computational performance. We focus on the repr…

q-bio.NC2015★ 26 cited

A three-threshold learning rule approaches the maximal capacity of recurrent neural networks

Alireza Alemi, Carlo Baldassi, Nicolas Brunel +1

Understanding the theoretical foundations of how memories are encoded and retrieved in neural populations is a central challenge in neuroscience. A popular theoretical scenario for…

cond-mat.dis-nn2015★ 18 cited

A Max-Sum algorithm for training discrete neural networks

Carlo Baldassi, Alfredo Braunstein

We present an efficient learning algorithm for the problem of training neural networks with discrete synapses, a well-known hard (NP-complete) discrete optimization problem. The al…

q-bio.MN2015★ 53 cited

Quantitative study of crossregulation, noise and synchronization between microRNA targets in single cells

Carla Bosia, Francesco Sgrò, Laura Conti +6

Recent studies reported complex post-transcriptional interplay among targets of a common pool of microRNAs, a class of small non-coding downregulators of gene expression. Behaving…

cond-mat.dis-nn2015★ 14 cited

The edge-disjoint path problem on random graphs by message-passing

Fabrizio Altarelli, Alfredo Braunstein, Luca Dall'Asta +2

We present a message-passing algorithm to solve the edge disjoint path problem (EDP) on graphs incorporating under a unique framework both traffic optimization and path length mini…

cond-mat.stat-mech2015★ 4 cited

Inference for interacting linear waves in ordered and random media

P. Tyagi, A. Pagnani, F. Antenucci +2

A statistical inference method is developed and tested for pairwise interacting systems whose degrees of freedom are continuous angular variables, such as planar spins in magnetic…