83 citations · 91 across the 8 of their papers we have counts for
5 papers · 1 filter
Sequence Space Localization in the Immune System Response to Vaccination and Disease
Michael W. Deem, Ha Youn Lee
We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccina…
Two-Dimensional Diffusion in the Presence of Topological Disorder
Ligang Chen, Michael W. Deem
How topological defects affect the dynamics of particles hopping between lattice sites of a distorted, two-dimensional crystal is addressed. Perturbation theory and numerical simul…
Monte Carlo Methods for Small Molecule High-Throughput Experimentation
Ligang Chen, Michael W. Deem
By analogy with Monte Carlo algorithms, we propose new strategies for design and redesign of small molecule libraries in high-throughput experimentation, or combinatorial chemistry…
A Statistical Mechanical Approach to Combinatorial Chemistry
Michael W. Deem
An analogy between combinatorial chemistry and Monte Carlo computer simulation is pursued. Examples of how to design libraries for both materials discovery and protein molecular ev…
Disorder-Induced Time-Dependent Diffusion in Zeolites
Ligang Chen, Marco Falcioni, Michael W. Deem
We suggest that disordered framework aluminums and non-framework cations can create a disordered electrostatic potential in zeolites that can lead to a discrepancy between diffusiv…