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Predicting Fixation Tendencies of the H3N2 Influenza Virus by Free Energy Calculation
Keyao Pan, Michael W. Deem
Influenza virus evolves to escape from immune system antibodies that bind to it. We used free energy calculations with Einstein crystals as reference states to calculate the differ…
Quantifying Influenza Vaccine Efficacy and Antigenic Distance
Vishal Gupta, David J. Earl, Michael W. Deem
We introduce a new measure of antigenic distance between influenza A vaccine and circulating strains. The measure correlates well with efficacies of the H3N2 influenza A component…
Epitope analysis for influenza vaccine design
Enrique T. Munoz, Michael W. Deem
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine…
Correlations in the T Cell Response to Altered Peptide Ligands
Jeong-Man Park, Michael W. Deem
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells…