1.3k citations · 3.4k across the 81 of their papers we have counts for
5 papers · 1 filter
Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma
Fengdan Ye, Dongya Jia, Mingyang Lu +2
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthes…
Analysis of hierarchical organization in gene expression networks reveals underlying principles of collective tumor cell dissemination and metastatic aggressiveness of inflammatory breast cancer
Shubham Tripathi, Mohit Kumar Jolly, Wendy A. Woodward +2
Clusters of circulating tumor cells (CTCs), although rare, may account for more than 95% of metastases. Inflammatory breast cancer (IBC) is a highly aggressive subtype that chiefly…
Hierarchy of Gene Expression Data is Predictive of Future Breast Cancer Outcome
Man Chen, Michael W. Deem
We calculate measures of hierarchy in gene and tissue networks of breast cancer patients. We find that the likelihood of metastasis in the future is correlated with increased value…
Spontaneous Emergence of Modularity in a Model of Evolving Individuals and in Real Networks
Jiankui He, Jun Sun, Michael W. Deem
We investigate the selective forces that promote the emergence of modularity in nature. We demonstrate the spontaneous emergence of modularity in a population of individuals that e…
Length, Protein-Protein Interactions, and Complexity
Taison Tan, Daan Frenkel, Vishal Gupta +1
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose her…