83 citations · 422 across the 17 of their papers we have counts for
10 papers · 1 filter
Theoretical Aspects of Immunity
Michael W. Deem, Pooya Hejazi
The immune system recognizes a myriad of invading pathogens and their toxic products. It does so with a finite repertoire of antibodies and T cell receptors. We here describe theor…
Computer-assisted vaccine design
Rao Zhou, Ramdas S. Pophale, Michael W. Deem
We define a new parameter to quantify the antigenic distance between two H3N2 influenza strains: we use this parameter to measure antigenic distance between circulating H3N2 strain…
Quasispecies Theory for Horizontal Gene Transfer and Recombination
Enrique Munoz, Jeong-Man Park, Michael W. Deem
We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a pop…
Spontaneous Emergence of Modularity in a Model of Evolving Individuals
Jun Sun, Michael W. Deem
We investigate the selective forces that promote the emergence of modularity in nature. We demonstrate the spontaneous emergence of modularity in a population of individuals that e…
Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer
Jeong-Man Park, Michael W. Deem
We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evol…
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System
Guanyu Wang, Michael W. Deem
Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclus…