Nonequilibrium sensing and its analogy to kinetic proofreading

Abstract

For a paradigmatic model of chemotaxis, we analyze the effect how a nonzero affinity driving receptors out of equilibrium affects sensitivity. This affinity arises whenever changes in receptor activity involve ATP hydrolysis. The sensitivity integrated over a ligand concentration range is shown to be enhanced by the affinity, providing a measure of how much energy consumption improves sensing. With this integrated sensitivity we can establish an intriguing analogy between sensing with nonequilibrium receptors and kinetic proofreading: the increase in integrated sensitivity is equivalent to the decrease of the error in kinetic proofreading. The influence of the occupancy of the receptor on the phosphorylation and dephosphorylation reaction rates is shown to be crucial for the relation between integrated sensitivity and affinity. This influence can even lead to a regime where a nonzero affinity decreases the integrated sensitivity, which corresponds to anti-proofreading.

17 pages, 7 figures

References in corpus (5)

• Thermodynamic costs of information processing in sensory adaption
• Efficiency of cellular information processing
• Thermodynamics of statistical inference by cells
• Information-theoretic vs. thermodynamic entropy production in autonomous sensory networks
• Predicting chemical environments of bacteria from receptor signaling

Cited by in corpus (3)

• Cost and Precision of Brownian Clocks
• Stochastic Thermodynamics of Learning
• Thermodynamic constraints on the nonequilibrium response of one-dimensional diffusions