Detecting concentration changes with cooperative receptors
arXiv:1507.07386 · doi:10.1007/s10955-015-1354-2
Abstract
Cells constantly need to monitor the state of the environment to detect changes and timely respond. The detection of concentration changes of a ligand by a set of receptors can be cast as a problem of hypothesis testing, and the cell viewed as a Neyman-Pearson detector. Within this framework, we investigate the role of receptor cooperativity in improving the cell's ability to detect changes. We find that cooperativity decreases the probability of missing an occurred change. This becomes especially beneficial when difficult detections have to be made. Concerning the influence of cooperativity on how fast a desired detection power is achieved, we find in general that there is an optimal value at finite levels of cooperation, even though easy discrimination tasks can be performed more rapidly by noncooperative receptors.
20 pages, 7 figures
References in corpus (10)
- Thermodynamic uncertainty relation for biomolecular processes
- Thermodynamic costs of information processing in sensory adaption
- Efficiency of cellular information processing
- Thermodynamics of statistical inference by cells
- Information-theoretic vs. thermodynamic entropy production in autonomous sensory networks
- Nonequilibrium sensing and its analogy to kinetic proofreading
- Memory improves precision of cell sensing in fluctuating environments
- Trade-offs in delayed information transmission in biochemical networks
- Cooperativity Can Enhance Cellular Signal Detection
- Properties of Cooperatively Induced Phases in Sensing Models