Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications

Abstract

We investigate performance and optimization of the "digital" bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the "branch point effect" similar to that encountered in biological systems. This corresponds to an "intensity filter," which can yield a binary-type sigmoid-response output signal of interest in information and signal processing and in biosensing applications. We define measures for optimizing the response for information processing applications based on the kinetic modeling of the enzymatic reactions involved, and apply the developed approach to the recently published data for glucose detection.

References in corpus (5)

• Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response
• Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications
• Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid "Filter" Response
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• Theoretical Modeling Expressions for Networked Enzymatic Signal Processing Steps as Logic Gates Optimized by Filtering
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