25 citations · 102 across the 8 of their papers we have counts for
8 papers
SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis
Sergii Domanskyi, Justin W. Nicholatos, Joshua E. Schilling +2
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient s…
Rate-Equation Modelling and Ensemble Approach to Extraction of Parameters for Viral Infection-Induced Cell Apoptosis and Necrosis
Sergii Domanskyi, Joshua E. Schilling, Vyacheslav Gorshkov +2
We develop a theoretical approach that uses physiochemical kinetics modelling to describe cell population dynamics upon progression of viral infection in cell culture, which result…
Diffusion of Oligonucleotides from within Iron-Crosslinked Polyelectrolyte-Modified Alginate Beads: A Model System for Drug Release
Vladimir Privman, Sergii Domanskyi, Roberto A. S. Luz +3
We developed and experimentally verified an analytical model to describe diffusion of oligonucleotides from stable hydrogel beads. The synthesized alginate beads are Fe3+-cross-lin…
Modeling and Modifying Response of Biochemical Processes for Biocomputing and Biosensing Signal Processing
Sergii Domanskyi, Vladimir Privman
Processes involving multi-input multi-step reaction cascades are used in developing novel biosensing, biocomputing, and decision making systems. In various applications different c…
Reaction-Diffusion Degradation Model for Delayed Erosion of Cross-Linked Polyanhydride Biomaterials
Sergii Domanskyi, Katie L. Poetz, Devon A. Shipp +1
We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently syn…
Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications
Vladimir Privman, Sergii Domanskyi, Shay Mailloux +2
A recently experimentally observed biochemical "threshold filtering" mechanism by processes catalyzed by the enzyme malate dehydrogenase is explained in terms of a model that incor…
Percolation Modeling of Self-Damaging of Composite Materials
Sergii Domanskyi, Vladimir Privman
We propose the concept of autonomous self-damaging in "smart" composite materials, controlled by activation of added nanosize "damaging" capsules. Percolation-type modeling approac…
Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications
Sergii Domanskyi, Vladimir Privman
We investigate performance and optimization of the "digital" bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into i…